UniProt functional annotation for Q8BL48



	UniProt functional annotation for Q8BL48

UniProt code: Q8BL48.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}.

Subcellular location: Cytoplasm {ECO:0000269|PubMed:25737280}.

Developmental stage: First expressed at 12 dpc and then expression declines postnatally. Highly expressed in the developing CNS (at protein level). {ECO:0000269|PubMed:25737280}.

Similarity: Belongs to the unkempt family. {ECO:0000305}.

Sequence caution: Sequence=BAC98248.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269\|PubMed:25737280}.


Subcellular location:		Cytoplasm {ECO:0000269\|PubMed:25737280}.
Developmental stage:		First expressed at 12 dpc and then expression declines postnatally. Highly expressed in the developing CNS (at protein level). {ECO:0000269\|PubMed:25737280}.
Similarity:		Belongs to the unkempt family. {ECO:0000305}.
Sequence caution:		Sequence=BAC98248.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};