|
|
||
|
|
|
|
|
UniProt functional annotation for Q9QLL6 | ||
|
|
|
|
|
|
||
| UniProt code: Q9QLL6. |
|
||
| Organism: | |
Influenza B virus (strain B/Lee/1940). |
| Taxonomy: | |
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; Insthoviricetes; Articulavirales; Orthomyxoviridae; Betainfluenzavirus. |
|
||
|
||
| Function: | |
Plays an essential role in transcription initiation and cap- stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds a wide range of cap structures of target pre-RNAs which are subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. {ECO:0000255|HAMAP- Rule:MF_04062, ECO:0000269|PubMed:33045004}. |
|
||
| Subunit: | |
Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus). Interacts with host ANP32A (via C-terminus) and ANP32B; these interactions promote viral RNA synthesis (PubMed:33045004). {ECO:0000255|HAMAP-Rule:MF_04062, ECO:0000269|PubMed:33045004}. |
| Subcellular location: | |
Virion {ECO:0000255|HAMAP-Rule:MF_04062}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04062}. |
| Similarity: | |
Belongs to the influenza viruses PB2 family. {ECO:0000255|HAMAP-Rule:MF_04062}. |
Annotations taken from UniProtKB at the EBI.