UniProt functional annotation for P09793



	UniProt functional annotation for P09793

UniProt code: P09793.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. {ECO:0000250|UniProtKB:P16410}.

Subunit: Homodimer; disulfide-linked. Binds to CD80/B7-1 and CD86/B7.2. Interacts with ICOSLG. {ECO:0000250|UniProtKB:P16410}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P16410}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P16410}. Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation;. {ECO:0000250|UniProtKB:P16410}.

Tissue specificity: Widely expressed with highest levels in lymphoid tissues. {ECO:0000269|PubMed:10493833}.

Ptm: N-glycosylation is important for dimerization. {ECO:0000250|UniProtKB:P16410}.

Ptm: Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface. {ECO:0000250|UniProtKB:P16410}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. {ECO:0000250\|UniProtKB:P16410}.


Subunit:		Homodimer; disulfide-linked. Binds to CD80/B7-1 and CD86/B7.2. Interacts with ICOSLG. {ECO:0000250\|UniProtKB:P16410}.
Subcellular location:		Cell membrane {ECO:0000250\|UniProtKB:P16410}; Single-pass type I membrane protein {ECO:0000250\|UniProtKB:P16410}. Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation;. {ECO:0000250\|UniProtKB:P16410}.
Tissue specificity:		Widely expressed with highest levels in lymphoid tissues. {ECO:0000269\|PubMed:10493833}.
Ptm:		N-glycosylation is important for dimerization. {ECO:0000250\|UniProtKB:P16410}.
Ptm:		Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface. {ECO:0000250\|UniProtKB:P16410}.