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UniProt functional annotation for Q9NY33 | ||
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| UniProt code: Q9NY33. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:3233187, PubMed:1515063). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:9425109, PubMed:3233187, PubMed:11209758). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}. |
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| Catalytic activity: | |
Reaction=Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.; EC=3.4.14.4; Evidence={ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:22493238, ECO:0000269|PubMed:9425109}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:22493238}; |
| Activity regulation: | |
Activated by Co(2+). Inhibited by EDTA and o- phenanthroline (in vitro). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}. |
| Biophysicochemical properties: | |
pH dependence: Optimum pH is 8.8. {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}; |
| Subcellular location: | |
Cytoplasm, cytosol {ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187}. |
| Tissue specificity: | |
Detected in placenta (at protein level) (PubMed:3233187). Detected in erythrocytes (at protein level) (PubMed:1515063). {ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187}. |
| Mass spectrometry: | |
Mass=82500; Mass_error=60; Method=MALDI; Evidence={ECO:0000269|PubMed:11209758}; |
| Miscellaneous: | |
[Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}. |
| Similarity: | |
Belongs to the peptidase M49 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.