UniProt functional annotation for Q94KI8



	UniProt functional annotation for Q94KI8

UniProt code: Q94KI8.

Organism: Arabidopsis thaliana (Mouse-ear cress).

Taxonomy: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.

Function: Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the vacuole membrane. Is one of the essential components of the slow vacuolar (SV) channel. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Involved in the regulation of germination and stomatal movement. {ECO:0000269|PubMed:15464979, ECO:0000269|PubMed:15772667}.

Activity regulation: Inhibited by Al(3+).

Subunit: Homodimer. {ECO:0000250}.

Subcellular location: Vacuole membrane {ECO:0000269|PubMed:15772667, ECO:0000269|PubMed:17151019}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:15772667}.

Tissue specificity: Ubiquitously expressed. {ECO:0000269|PubMed:11577183}.

Domain: Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage- sensor and are characterized by a series of positively charged amino acids (By similarity). {ECO:0000250}.

Disruption phenotype: Plants display an impairment of both the Ca(2+) inhibition of stomatal guard cell opening and abscisic acid (ABA) inhibition of seed germination. {ECO:0000269|PubMed:15772667}.

Similarity: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily. {ECO:0000305}.

Sequence caution: Sequence=AAD11598.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAD15312.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB77841.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Arabidopsis thaliana (Mouse-ear cress).
Taxonomy:		Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.



Function:		Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the vacuole membrane. Is one of the essential components of the slow vacuolar (SV) channel. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Involved in the regulation of germination and stomatal movement. {ECO:0000269\|PubMed:15464979, ECO:0000269\|PubMed:15772667}.


Activity regulation:		Inhibited by Al(3+).
Subunit:		Homodimer. {ECO:0000250}.
Subcellular location:		Vacuole membrane {ECO:0000269\|PubMed:15772667, ECO:0000269\|PubMed:17151019}; Multi-pass membrane protein {ECO:0000255, ECO:0000269\|PubMed:15772667}.
Tissue specificity:		Ubiquitously expressed. {ECO:0000269\|PubMed:11577183}.
Domain:		Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage- sensor and are characterized by a series of positively charged amino acids (By similarity). {ECO:0000250}.
Disruption phenotype:		Plants display an impairment of both the Ca(2+) inhibition of stomatal guard cell opening and abscisic acid (ABA) inhibition of seed germination. {ECO:0000269\|PubMed:15772667}.
Similarity:		Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily. {ECO:0000305}.
Sequence caution:		Sequence=AAD11598.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAD15312.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB77841.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};