UniProt functional annotation for Q91XZ4



	UniProt functional annotation for Q91XZ4

UniProt code: Q91XZ4.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (PubMed:27161523). Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain (PubMed:27161523). {ECO:0000269|PubMed:27161523}.

Subunit: Forms homodimers in trans (molecules expressed by two different cells). Forms promiscuous heterodimers in cis (at the plasma membrane of the same cell) with other protocadherins. {ECO:0000269|PubMed:27161523}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:27161523}; Single-pass type I membrane protein {ECO:0000269|PubMed:27161523}.

Domain: Cadherin 1 to cadherin 4 domains mediate homophilic trans- interaction, the interaction with an identical protocadherin expressed by a neighboring cell (PubMed:27161523). This is a head-to-tail interaction, the cadherin 1 domain interacting with the cadherin 4 domain and the cadherin 2 domain interacting the cadherin 3 domain of the other protocadherin (PubMed:27161523). The cadherin 6 domain mediates promiscuous interactions with protocadherins on the same cell membrane (PubMed:27161523). Each cadherin domain binds three calcium ions (PubMed:27161523). {ECO:0000269|PubMed:27161523, ECO:0000312|PDB:5DZX}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (PubMed:27161523). Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain (PubMed:27161523). {ECO:0000269\|PubMed:27161523}.


Subunit:		Forms homodimers in trans (molecules expressed by two different cells). Forms promiscuous heterodimers in cis (at the plasma membrane of the same cell) with other protocadherins. {ECO:0000269\|PubMed:27161523}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:27161523}; Single-pass type I membrane protein {ECO:0000269\|PubMed:27161523}.
Domain:		Cadherin 1 to cadherin 4 domains mediate homophilic trans- interaction, the interaction with an identical protocadherin expressed by a neighboring cell (PubMed:27161523). This is a head-to-tail interaction, the cadherin 1 domain interacting with the cadherin 4 domain and the cadherin 2 domain interacting the cadherin 3 domain of the other protocadherin (PubMed:27161523). The cadherin 6 domain mediates promiscuous interactions with protocadherins on the same cell membrane (PubMed:27161523). Each cadherin domain binds three calcium ions (PubMed:27161523). {ECO:0000269\|PubMed:27161523, ECO:0000312\|PDB:5DZX}.