UniProt functional annotation for O55164



	UniProt functional annotation for O55164

UniProt code: O55164.

Organism: Rattus norvegicus (Rat).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.

Function: Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:15312654). Promotes clustering of HT2RC at the cell surface (PubMed:11150294). {ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}.

Subunit: Interacts with F11R/JAM, CLDN1, NG2, CXADR, CRB1, MPP4 and PALS1, HTR2A, HTR2B, PLEKHA1/TAPP1 and PLEKHA2/TAPP2. Interacts with CXADR (By similarity). Interacts with HTR2C, CLDN5, DLG4, GRIN1, SYNGAP1, CAMK2A and CAMK2B. Interacts with FAT4 (via cytoplasmic domain) (By similarity). Interacts with DLL1 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q8VBX6, ECO:0000269|PubMed:11000240, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:12403818, ECO:0000269|PubMed:15312654, ECO:0000269|PubMed:15863617}.

Subcellular location: Endomembrane system. Cell junction, tight junction. Cell junction, synapse. Apical cell membrane {ECO:0000269|PubMed:11150294}. Cell junction, synapse, postsynaptic density. Cell projection, dendrite. Cell junction, synapse, synaptosome. Note=Associated with membranes. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR. In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane (By similarity). Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells (PubMed:11150294). Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. {ECO:0000250, ECO:0000269|PubMed:11150294}.

Tissue specificity: Abundant in all cerebral cortical layers, especially the piriform cortex, the pyramidal cells of the CA1-CA3 subfields of the hippocampus, as well as the granular layer of the dentate gyrus. Detected in the internal granular layer and the mitral cell layer of the olfactory bulb; in the medial habenular nucleus; and in amygdaloid, thalamic, hypothalamic, and pontine nuclei. In the cerebellum, found at high levels in the granular layer. Detected in the lateral ventricle. Expression overlaps with 5-HT2C receptor expression in all regions of the brain including the choroid plexus, where 5-HT2C receptors are highly enriched. {ECO:0000269|PubMed:11150294}.

Domain: The PDZ domain 1 binds NG2. The PDZ domain 2 mainly binds CAMK2A and CAMK2B. The PDZ domain 9 binds F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT. The PDZ domains 10 and 13 bind PLEKHA1 and PLEKHA2. The PDZ domain 13 binds CXADR and SYNGAP1 (By similarity). The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 10 binds the C-terminal PDZ-binding motif of HTR2C. {ECO:0000250, ECO:0000269|PubMed:11000240, ECO:0000269|PubMed:11150294}.

Miscellaneous: Sequestered into cytoplasmic, detergent-resistant bodies upon Ad9 E4-ORF1 oncoprotein expression. Targeted to degradation upon HPV-18 E6 oncoprotein expression.

Annotations taken from UniProtKB at the EBI.


Organism:		Rattus norvegicus (Rat).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.



Function:		Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:15312654). Promotes clustering of HT2RC at the cell surface (PubMed:11150294). {ECO:0000269\|PubMed:11150294, ECO:0000269\|PubMed:15312654}.


Subunit:		Interacts with F11R/JAM, CLDN1, NG2, CXADR, CRB1, MPP4 and PALS1, HTR2A, HTR2B, PLEKHA1/TAPP1 and PLEKHA2/TAPP2. Interacts with CXADR (By similarity). Interacts with HTR2C, CLDN5, DLG4, GRIN1, SYNGAP1, CAMK2A and CAMK2B. Interacts with FAT4 (via cytoplasmic domain) (By similarity). Interacts with DLL1 (By similarity). {ECO:0000250, ECO:0000250\|UniProtKB:Q8VBX6, ECO:0000269\|PubMed:11000240, ECO:0000269\|PubMed:11150294, ECO:0000269\|PubMed:12403818, ECO:0000269\|PubMed:15312654, ECO:0000269\|PubMed:15863617}.
Subcellular location:		Endomembrane system. Cell junction, tight junction. Cell junction, synapse. Apical cell membrane {ECO:0000269\|PubMed:11150294}. Cell junction, synapse, postsynaptic density. Cell projection, dendrite. Cell junction, synapse, synaptosome. Note=Associated with membranes. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR. In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane (By similarity). Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells (PubMed:11150294). Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. {ECO:0000250, ECO:0000269\|PubMed:11150294}.
Tissue specificity:		Abundant in all cerebral cortical layers, especially the piriform cortex, the pyramidal cells of the CA1-CA3 subfields of the hippocampus, as well as the granular layer of the dentate gyrus. Detected in the internal granular layer and the mitral cell layer of the olfactory bulb; in the medial habenular nucleus; and in amygdaloid, thalamic, hypothalamic, and pontine nuclei. In the cerebellum, found at high levels in the granular layer. Detected in the lateral ventricle. Expression overlaps with 5-HT2C receptor expression in all regions of the brain including the choroid plexus, where 5-HT2C receptors are highly enriched. {ECO:0000269\|PubMed:11150294}.
Domain:		The PDZ domain 1 binds NG2. The PDZ domain 2 mainly binds CAMK2A and CAMK2B. The PDZ domain 9 binds F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT. The PDZ domains 10 and 13 bind PLEKHA1 and PLEKHA2. The PDZ domain 13 binds CXADR and SYNGAP1 (By similarity). The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 10 binds the C-terminal PDZ-binding motif of HTR2C. {ECO:0000250, ECO:0000269\|PubMed:11000240, ECO:0000269\|PubMed:11150294}.
Miscellaneous:		Sequestered into cytoplasmic, detergent-resistant bodies upon Ad9 E4-ORF1 oncoprotein expression. Targeted to degradation upon HPV-18 E6 oncoprotein expression.