PDBsum entry 5dkh

Transcription

PDB id: 5dkh

Contents

Protein chains

116 a.a.

110 a.a.

Ligands

5C0 ×2

EDO ×2

Metals

_ZN ×6

Waters ×177

PDB id:

5dkh

Name:

Transcription

Title:

Crystal structure of the bromodomain of human brm (smarca2) in complex with a hydroxyphenyl propenone inhibitor 17

Structure:

Probable global transcription activator snf2l2. Chain: a, b, c. Fragment: unp residues 1373-1493. Synonym: atp-dependent helicase smarca2,brg1-associated factor 190b, baf190b,protein brahma homolog,hbrm,snf2-alpha,swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a member 2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: smarca2, baf190b, brm, snf2a, snf2l2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.70Å R-factor: 0.201 R-free: 0.241

Authors:

C.Tallant,D.R.Owen,A.Taylor,O.Fedorov,P.Savitsky,P.Siejka, V.Srikannathasan,R.Nowak,F.Von Delft,C.H.Arrowsmith,A.M.Edwards, C.Bountra,S.Knapp

Key ref:

C.Tallant et al. Crystal structure of the bromodomain of human brm (sm in complex with a hydroxyphenyl propenone inhibitor 1. To be published, .

Date:

03-Sep-15 Release date: 14-Sep-16

Protein chain

P51531  (SMCA2_HUMAN) -  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 from Homo sapiens

Seq: 1590 a.a.

Struc: 116 a.a.

Protein chains

P51531  (SMCA2_HUMAN) -  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 from Homo sapiens

Seq: 1590 a.a.

Struc: 110 a.a.

Enzyme reactions

• Enzyme class: Chains A, B, C: E.C.3.6.4.- - ?????