PDBsum entry 5dkd

Hydrolase

PDB id: 5dkd

Contents

Protein chains

110 a.a.

Ligands

EDO ×6

5BW ×2

Metals

_ZN ×2

Waters ×101

PDB id:

5dkd

Name:

Hydrolase

Title:

Crystal structure of the bromodomain of human brg1 (smarca4) in complex with pfi-3 chemical probe

Structure:

Transcription activator brg1. Chain: a, b. Fragment: unp residues 1418-1536. Synonym: atp-dependent helicase smarca4,brg1-associated factor 190a, baf190a,mitotic growth and transcription activator,protein brg-1, protein brahma homolog 1,snf2-beta,swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a member 4. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: smarca4, baf190a, brg1, snf2b, snf2l4. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.00Å R-factor: 0.269 R-free: 0.297

Authors:

C.Tallant,D.R.Owen,B.S.Gerstenberger,O.Fedorov,P.Savitsky,G.Nunez- Alonso,J.A.Newman,P.Filippakopoulos,N.Burgess-Brown,F.Von Delft, C.H.Arrowsmith,A.M.Edwards,C.Bountra,S.Muller,S.Knapp

Key ref:

C.Tallant et al. Crystal structure of the bromodomain of human brg1 (s in complex with pfi-3 chemical probe. To be published, .

Date:

03-Sep-15 Release date: 14-Oct-15

Protein chains

P51532  (SMCA4_HUMAN) -  Transcription activator BRG1 from Homo sapiens

Seq: 1647 a.a.

Struc: 110 a.a.

Enzyme reactions

• Enzyme class: E.C.3.6.4.- - ?????