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PDBsum entry 5dad
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Transcription
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PDB id
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5dad
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PDB id:
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| Name: |
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Transcription
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Title:
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Crystal structure of human keap1 btb domain in complex with small molecule tx64014
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Structure:
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Kelch-like ech-associated protein 1. Chain: a. Fragment: btb domain, residues 49-182. Synonym: cytosolic inhibitor of nrf2,inrf2,kelch-like protein 19. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: keap1, inrf2, kiaa0132, klhl19. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.61Å
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R-factor:
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0.206
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R-free:
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0.245
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Authors:
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C.Huerta,X.Jiang,I.Trevino,C.F.Bender,K.K.Swinger,V.S.Stoll, D.A.Ferguson,P.J.Thomas,B.Probst,I.Dulubova,M.Visnick,W.C.Wigley
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Key ref:
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C.Huerta
et al.
(2016).
Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding.
Biochim Biophys Acta,
1860,
2537-2552.
PubMed id:
DOI:
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Date:
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19-Aug-15
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Release date:
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10-Aug-16
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PROCHECK
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Headers
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References
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Q14145
(KEAP1_HUMAN) -
Kelch-like ECH-associated protein 1 from Homo sapiens
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Seq:
Struc:
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624 a.a.
123 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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DOI no:
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Biochim Biophys Acta
1860:2537-2552
(2016)
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PubMed id:
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Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding.
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C.Huerta,
X.Jiang,
I.Trevino,
C.F.Bender,
D.A.Ferguson,
B.Probst,
K.K.Swinger,
V.S.Stoll,
P.J.Thomas,
I.Dulubova,
M.Visnick,
W.C.Wigley.
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ABSTRACT
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Links
