PDBsum entry 5da3

Transferase/transferase inhibitor

PDB id: 5da3

Contents

Protein chain

264 a.a.

Ligands

GOL ×2

58V

Waters ×192

PDB id:

5da3

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of ptk6 kinase domain with inhibitor

Structure:

Protein-tyrosine kinase 6. Chain: a. Fragment: kinase domain, unp residues 185-446. Synonym: breast tumor kinase,tyrosine-protein kinase brk. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Resolution:

1.70Å R-factor: 0.199 R-free: 0.230

Authors:

M.K.Thakur,S.Birudukota,S.Swaminathan,S.K.Battula,S.Vadivelu,R.Tyagi, R.Gosu

Key ref:

M.K.Thakur et al. (2017). Co-crystal structures of PTK6: With Dasatinib at 2.24 Å, with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 Å resolution. Biochem Biophys Res Commun, 482, 1289-1295. PubMed id: 27993680 DOI: 10.1016/j.bbrc.2016.12.030

Date:

19-Aug-15 Release date: 24-Aug-16

Protein chain

Q13882  (PTK6_HUMAN) -  Protein-tyrosine kinase 6 from Homo sapiens

Seq: 451 a.a.

Struc: 264 a.a.*

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1016/j.bbrc.2016.12.030

Biochem Biophys Res Commun 482:1289-1295 (2017)

PubMed id: 27993680

Co-crystal structures of PTK6: With Dasatinib at 2.24 Å, with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 Å resolution.

M.K.Thakur, S.Birudukota, S.Swaminathan, S.K.Battula, S.Vadivelu, R.Tyagi, R.Gosu.

ABSTRACT

No abstract given.