PDBsum entry 5czv

Immune system

PDB id: 5czv

Contents

Protein chains

225 a.a.

206 a.a.

211 a.a.

Ligands

NAG

Metals

_CA ×3

Waters ×7

PDB id:

5czv

Name:

Immune system

Title:

Crystal structure of notch3 nrr in complex with 20350 fab

Structure:

Neurogenic locus notch homolog protein 3. Chain: a. Fragment: negative regulatory region (unp residues 1378-1640). Synonym: notch 3. Engineered: yes. Fab 20350 heavy chain. Chain: h. Synonym: igg20350 heavy chain, nvp-lmw976 heavy chain. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: notch3. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293-fs. Expression_system_cell_line: hek293.

Resolution:

3.19Å R-factor: 0.206 R-free: 0.257

Authors:

T.Hu,C.Fryer,R.Chopra,K.Clark

Key ref:

P.Bernasconi-Elias et al. (2016). Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene, 35, 6077-6086. PubMed id: 27157619 DOI: 10.1038/onc.2016.133

Date:

01-Aug-15 Release date: 01-Jun-16

Protein chain

Q9UM47  (NOTC3_HUMAN) -  Neurogenic locus notch homolog protein 3 from Homo sapiens

Seq: 2321 a.a.

Struc: 225 a.a.

Protein chain

No UniProt id for this chain

Struc: 206 a.a.

Protein chain

No UniProt id for this chain

Struc: 211 a.a.

DOI no: 10.1038/onc.2016.133

Oncogene 35:6077-6086 (2016)

PubMed id: 27157619

Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies.

P.Bernasconi-Elias, T.Hu, D.Jenkins, B.Firestone, S.Gans, E.Kurth, P.Capodieci, J.Deplazes-Lauber, K.Petropoulos, P.Thiel, D.Ponsel, S.Hee Choi, P.LeMotte, A.London, M.Goetcshkes, E.Nolin, M.D.Jones, K.Slocum, M.J.Kluk, D.M.Weinstock, A.Christodoulou, O.Weinberg, J.Jaehrling, S.A.Ettenberg, A.Buckler, S.C.Blacklow, J.C.Aster, C.J.Fryer.

ABSTRACT

No abstract given.