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UniProt functional annotation for G0SFB5 | ||
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| UniProt code: G0SFB5. |
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| Organism: | |
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium. |
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| Function: | |
Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}. |
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| Subunit: | |
Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome (PubMed:26476442, PubMed:26657628). Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain) (By similarity). {ECO:0000250|UniProtKB:Q12024, ECO:0000255|HAMAP-Rule:MF_03029, ECO:0000269|PubMed:26476442, ECO:0000269|PubMed:26657628}. |
| Subcellular location: | |
Nucleus, nucleolus {ECO:0000255|HAMAP- Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}. |
| Similarity: | |
Belongs to the WD repeat WDR12/YTM1 family. {ECO:0000255|HAMAP-Rule:MF_03029}. |
Annotations taken from UniProtKB at the EBI.