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PDBsum entry 5bxu
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PDB id:
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Transferase
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Title:
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Human tankyrase-2 in complex with macrocyclised extended peptide cp4n4m5
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Structure:
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Tankyrase-2. Chain: a. Fragment: residues 488-649. Synonym: tank2,adp-ribosyltransferase diphtheria toxin-like 6,artd6, poly [adp-ribose] polymerase 5b,tnks-2,trf1-interacting ankyrin- related adp-ribose polymerase 2,tankyrase ii,tankyrase-like protein, tankyrase-related protein. Engineered: yes. Cp4n4m5.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
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Resolution:
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1.35Å
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R-factor:
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0.158
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R-free:
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0.186
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Authors:
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W.Xu,G.Fischer,M.Hyvonen,L.Itzhaki
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Key ref:
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W.Xu
et al.
Human tankyrase-2 in complex with extended stapled pe sp4n4m5.
To be published,
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PubMed id:
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Date:
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09-Jun-15
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Release date:
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29-Jun-16
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PROCHECK
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Headers
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References
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Q9H2K2
(TNKS2_HUMAN) -
Poly [ADP-ribose] polymerase tankyrase-2 from Homo sapiens
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Seq:
Struc:
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1166 a.a.
163 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class 2:
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E.C.2.4.2.-
- ?????
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Enzyme class 3:
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E.C.2.4.2.30
- NAD(+) ADP-ribosyltransferase.
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Pathway:
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Reaction:
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NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D- ribosyl)n+1-acceptor + H+
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NAD(+)
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+
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(ADP-D-ribosyl)n-acceptor
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=
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nicotinamide
Bound ligand (Het Group name = )
matches with 66.67% similarity
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+
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(ADP-D- ribosyl)n+1-acceptor
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
