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PDBsum entry 5bq0
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Transferase/transferase inhibitor
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PDB id
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5bq0
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References listed in PDB file
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Key reference
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Title
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Design and synthesis of carbazole carboxamides as promising inhibitors of bruton'S tyrosine kinase (btk) and janus kinase 2 (jak2).
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Authors
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Q.Liu,
D.G.Batt,
J.S.Lippy,
N.Surti,
A.J.Tebben,
J.K.Muckelbauer,
L.Chen,
Y.An,
C.Chang,
M.Pokross,
Z.Yang,
H.Wang,
J.R.Burke,
P.H.Carter,
J.A.Tino.
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Ref.
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Bioorg Med Chem Lett, 2015,
25,
4265-4269.
[DOI no: ]
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PubMed id
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Abstract
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Four series of disubstituted carbazole-1-carboxamides were designed and
synthesised as inhibitors of Bruton's tyrosine kinase (BTK). 4,7- and
4,6-disubstituted carbazole-1-carboxamides were potent and selective inhibitors
of BTK, while 3,7- and 3,6-disubstituted carbazole-1-carboxamides were potent
and selective inhibitors of Janus kinase 2 (JAK2).
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