PDBsum entry 5bmm

Transferase/transferase inhibitor

PDB id: 5bmm

Contents

Protein chains

275 a.a.

Ligands

FUM-ALC-PFF-PPN-ORN ×2

Waters ×130

PDB id:

5bmm

Name:

Transferase/transferase inhibitor

Title:

Src in complex with DNA-templated macrocyclic inhibitor mc25b

Structure:

Proto-oncogene tyrosine-protein kinase src. Chain: a, b. Synonym: proto-oncogenE C-src,pp60c-src,p60-src. Engineered: yes. Macrocyclic inhibitor mc25b. Chain: c, d. Engineered: yes

Source:

Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630

Resolution:

2.50Å R-factor: 0.220 R-free: 0.246

Authors:

G.Georghiou,K.E.Guja,S.Aleem,R.E.Kleiner,D.R.Liu,W.T.Miller,M.Garcia- Diaz,M.A.Seeliger

Key ref:

S.U.Aleem et al. (2016). Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles. Cell Chem Biol, 23, 1103-1112. PubMed id: 27593110 DOI: 10.1016/j.chembiol.2016.07.017

Date:

22-May-15 Release date: 21-Sep-16

Protein chains

P00523  (SRC_CHICK) -  Proto-oncogene tyrosine-protein kinase Src from Gallus gallus

Seq: 533 a.a.

Struc: 275 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1016/j.chembiol.2016.07.017

Cell Chem Biol 23:1103-1112 (2016)

PubMed id: 27593110

Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles.

S.U.Aleem, G.Georghiou, R.E.Kleiner, K.E.Guja, B.P.Craddock, A.Lyczek, A.I.Chan, M.Garcia-Diaz, W.T.Miller, D.R.Liu, M.A.Seeliger.

ABSTRACT

No abstract given.