PDBsum entry 5b76

Transferase

PDB id: 5b76

Contents

Protein chains

120 a.a.

26 a.a.

Ligands

SO4 ×3

Metals

_ZN ×4

Waters ×180

PDB id:

5b76

Name:

Transferase

Title:

Crystal structure of moz double phd finger domain in complex with histone h3 crotonylation at k14

Structure:

Histone acetyltransferase kat6a. Chain: a. Fragment: unp residues 194-323. Synonym: moz. Engineered: yes. Histone h3. Chain: b. Fragment: unp residues 2-26. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: moz. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Resolution:

1.65Å R-factor: 0.189 R-free: 0.237

Authors:

H.Li,X.Xiong

Key ref:

X.Xiong et al. (2016). Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2. Nat Chem Biol, 12, 1111-1118. PubMed id: 27775714 DOI: 10.1038/nchembio.2218

Date:

05-Jun-16 Release date: 26-Oct-16

Protein chain

Q92794  (KAT6A_HUMAN) -  Histone acetyltransferase KAT6A from Homo sapiens

Seq: 2004 a.a.

Struc: 120 a.a.*

Protein chain

K7EMV3  (K7EMV3_HUMAN) -  Histone H3 from Homo sapiens

Seq: 92 a.a.

Struc: 26 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.2.3.1.48 - histone acetyltransferase.
• Reaction: L-lysyl-[protein] + acetyl-CoA = N₆-acetyl-L-lysyl-[protein] + CoA + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1038/nchembio.2218

Nat Chem Biol 12:1111-1118 (2016)

PubMed id: 27775714

Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2.

X.Xiong, T.Panchenko, S.Yang, S.Zhao, P.Yan, W.Zhang, W.Xie, Y.Li, Y.Zhao, C.D.Allis, H.Li.

ABSTRACT

No abstract given.