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PDBsum entry 5b38
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Immune system
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PDB id
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5b38
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Contents |
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275 a.a.
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99 a.a.
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273 a.a.
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References listed in PDB file
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Key reference
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Title
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Killer cell immunoglobulin-Like receptor 3dl1 polymorphism defines distinct hierarchies of hla class i recognition.
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Authors
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P.M.Saunders,
P.Pymm,
G.Pietra,
V.A.Hughes,
C.Hitchen,
G.M.O'Connor,
F.Loiacono,
J.Widjaja,
D.A.Price,
M.Falco,
M.C.Mingari,
L.Moretta,
D.W.Mcvicar,
J.Rossjohn,
A.G.Brooks,
J.P.Vivian.
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Ref.
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J Exp Med, 2016,
213,
791-807.
[DOI no: ]
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PubMed id
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Note: In the PDB file this reference is
annotated as "TO BE PUBLISHED". The citation details given above have
been manually determined.
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Abstract
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Natural killer (NK) cells play a key role in immunity, but how HLA class I
(HLA-I) and killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) polymorphism
impacts disease outcome remains unclear. KIR3DL1 (*001/*005/*015) tetramers were
screened for reactivity against a panel of HLA-I molecules. This revealed
different and distinct hierarchies of specificity for each KIR3DL1 allotype,
with KIR3DL1*005 recognizing the widest array of HLA-I ligands. These
differences were further reflected in functional studies using NK clones
expressing these specific KIR3DL1 allotypes. Unexpectedly, the Ile/Thr80
dimorphism in the Bw4-motif did not categorically define strong/weak KIR3DL1
recognition. Although the KIR3DL1*001, *005, and *015 polymorphisms are remote
from the KIR3DL1-HLA-I interface, the structures of these three KIR3DL1-HLA-I
complexes showed that the broader HLA-I specificity of KIR3DL1*005 correlated
with an altered KIR3DL1*005 interdomain positioning and increased mobility
within its ligand-binding site. Collectively, we provide a generic framework for
understanding the impact of KIR3DL1 polymorphism on the recognition of HLA-I
allomorphs.
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