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PDBsum entry 5b1x
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Carbohydrate binding protein
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PDB id
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5b1x
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References listed in PDB file
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Key reference
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Title
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Crystal structure of human dendritic cell inhibitory receptor c-Type lectin domain reveals the binding mode with n-Glycan.
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Authors
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M.Nagae,
A.Ikeda,
S.Hanashima,
T.Kojima,
N.Matsumoto,
K.Yamamoto,
Y.Yamaguchi.
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Ref.
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Febs Lett, 2016,
590,
1280-1288.
[DOI no: ]
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PubMed id
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Abstract
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Human dendritic cell inhibitory receptor (DCIR) is a C-type lectin receptor
expressed in classical dendritic cells and accepts several oligosaccharide
ligands including N-glycans. Here, we report the crystal structures of human
DCIR C-type lectin domains in the absence and presence of a branched N-glycan
unit. The domain has a typical C-type lectin fold and two bound calcium ions. In
the ligand-bound form, the disaccharide unit (GlcNAcβ1-2Man) acceptably fits
the electron density map, indicating that it forms the main epitope. The
recognition of the nonterminal N-glycan unit explains the relatively broad
specificity of this lectin.
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