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PDBsum entry 5b0o
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Hydrolase/motor protein
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PDB id
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5b0o
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Contents |
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445 a.a.
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(+ 0 more)
135 a.a.
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126 a.a.
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127 a.a.
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References listed in PDB file
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Key reference
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Title
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Insight into the flagella type III export revealed by the complex structure of the type III atpase and its regulator.
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Authors
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K.Imada,
T.Minamino,
Y.Uchida,
M.Kinoshita,
K.Namba.
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Ref.
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Proc Natl Acad Sci U S A, 2016,
113,
3633-3638.
[DOI no: ]
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PubMed id
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Abstract
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FliI and FliJ form the FliI6FliJ ATPase complex of the bacterial flagellar
export apparatus, a member of the type III secretion system. The FliI6FliJ
complex is structurally similar to the α3β3γ complex of F1-ATPase. The FliH
homodimer binds to FliI to connect the ATPase complex to the flagellar base, but
the details are unknown. Here we report the structure of the homodimer of a
C-terminal fragment of FliH (FliHC2) in complex with FliI. FliHC2shows an
unusually asymmetric homodimeric structure that markedly resembles the
peripheral stalk of the A/V-type ATPases. The FliHC2-FliI hexamer model reveals
that the C-terminal domains of the FliI ATPase face the cell membrane in a way
similar to the F/A/V-type ATPases. We discuss the mechanism of flagellar ATPase
complex formation and a common origin shared by the type III secretion system
and the F/A/V-type ATPases.
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Secondary reference #1
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Title
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Crystallization and preliminary X-Ray analysis of the flih-Flii complex responsible for bacterial flagellar type III protein export.
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Authors
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Y.Uchida,
T.Minamino,
K.Namba,
K.Imada.
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Ref.
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Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012,
68,
1311-1314.
[DOI no: ]
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PubMed id
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