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PDBsum entry 5an8
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Transport protein
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PDB id
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5an8
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References listed in PDB file
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Key reference
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Title
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Cryo-Electron microscopy structure of the trpv2 ion channel.
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Authors
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L.Zubcevic,
M.A.Herzik,
B.C.Chung,
Z.Liu,
G.C.Lander,
S.Y.Lee.
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Ref.
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Nat Struct Biol, 2016,
23,
180-186.
[DOI no: ]
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PubMed id
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Note: In the PDB file this reference is
annotated as "TO BE PUBLISHED". The citation details given above have
been manually determined.
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Abstract
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Transient receptor potential vanilloid (TRPV) cation channels are polymodal
sensors involved in a variety of physiological processes. TRPV2, a member of the
TRPV family, is regulated by temperature, by ligands, such as probenecid and
cannabinoids, and by lipids. TRPV2 has been implicated in many biological
functions, including somatosensation, osmosensation and innate immunity. Here we
present the atomic model of rabbit TRPV2 in its putative desensitized state, as
determined by cryo-EM at a nominal resolution of ∼4 Å. In the TRPV2
structure, the transmembrane segment 6 (S6), which is involved in gate opening,
adopts a conformation different from the one observed in TRPV1. Structural
comparisons of TRPV1 and TRPV2 indicate that a rotation of the ankyrin-repeat
domain is coupled to pore opening via the TRP domain, and this pore opening can
be modulated by rearrangements in the secondary structure of S6.
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