PDBsum entry 5am7

Transferase

PDB id: 5am7

Contents

Protein chains

294 a.a.

Ligands

38O ×2

Metals

_CL ×3

Waters ×217

PDB id:

5am7

Name:

Transferase

Title:

Fgfr1 mutant with an inhibitor

Structure:

Fibroblast growth factor receptor 1. Chain: a, b. Fragment: kinase domain, unp residues 458-765. Synonym: fgfr-1, basic fibroblast growth factor receptor 1, bfgfr, bfgf-r-1, fms-like tyrosine kinase 2, flt-2, n-sam, proto-oncogenE C- fgr, fibroblast growth factor 1. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: c41 lambda 37.

Resolution:

1.96Å R-factor: 0.201 R-free: 0.254

Authors:

T.D.Bunney,S.Wan,N.Thiyagarajan,L.Sutto,S.V.Williams,P.Ashford, H.Koss,M.A.Knowles,F.L.Gervasio,P.V.Coveney,M.Katan

Key ref:

T.D.Bunney et al. (2015). The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study. Ebiomedicine, 2, 194-204. PubMed id: 26097890 DOI: 10.1016/j.ebiom.2015.02.009

Date:

10-Mar-15 Release date: 18-Mar-15

Supersedes:

4ux0

Protein chains

P11362  (FGFR1_HUMAN) -  Fibroblast growth factor receptor 1 from Homo sapiens

Seq: 822 a.a.

Struc: 294 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1016/j.ebiom.2015.02.009

Ebiomedicine 2:194-204 (2015)

PubMed id: 26097890

The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study.

T.D.Bunney, S.Wan, N.Thiyagarajan, L.Sutto, S.V.Williams, P.Ashford, H.Koss, M.A.Knowles, F.L.Gervasio, P.V.Coveney, M.Katan.

ABSTRACT

No abstract given.