PDBsum entry 5ad2

Transcription

PDB id: 5ad2

Contents

Protein chains

127 a.a.

Ligands

ETU

Waters ×257

PDB id:

5ad2

Name:

Transcription

Title:

Bivalent binding to bet bromodomains

Structure:

Bromodomain-containing protein 4. Chain: a, b. Fragment: bromodomain 1, residues 44-168. Synonym: protein hunk1, brd4. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.01Å R-factor: 0.182 R-free: 0.236

Authors:

M.J.Waring,H.Chen,A.A.Rabow,G.Walker,R.Bobby,S.Boiko,R.H.Bradbury, R.Callis,I.Dale,D.Daniels,L.Flavell,G.Holdgate,T.A.Jowitt,A.Kikhney, M.Mcalister,D.Ogg,J.Patel,P.Petteruti,G.R.Robb,M.Robers,N.Stratton, D.I.Svergun,W.Wang,D.Whittaker

Key ref:

M.J.Waring et al. (2016). Potent and selective bivalent inhibitors of BET bromodomains. Nat Chem Biol, 12, 1097-1104. PubMed id: 27775716 DOI: 10.1038/nchembio.2210

Date:

19-Aug-15 Release date: 28-Sep-16

Protein chains

O60885  (BRD4_HUMAN) -  Bromodomain-containing protein 4 from Homo sapiens

Seq: 1362 a.a.

Struc: 127 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.?

DOI no: 10.1038/nchembio.2210

Nat Chem Biol 12:1097-1104 (2016)

PubMed id: 27775716

Potent and selective bivalent inhibitors of BET bromodomains.

M.J.Waring, H.Chen, A.A.Rabow, G.Walker, R.Bobby, S.Boiko, R.H.Bradbury, R.Callis, E.Clark, I.Dale, D.L.Daniels, A.Dulak, L.Flavell, G.Holdgate, T.A.Jowitt, A.Kikhney, M.McAlister, J.Méndez, D.Ogg, J.Patel, P.Petteruti, G.R.Robb, M.B.Robers, S.Saif, N.Stratton, D.I.Svergun, W.Wang, D.Whittaker, D.M.Wilson, Y.Yao.

ABSTRACT

No abstract given.