 |
PDBsum entry 5abd
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Signaling protein
|
PDB id
|
|
|
|
5abd
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Signaling protein
|
|
|
Title:
|
|
Crystal structure of vegfr-1 domain 2 in presence of cu
|
|
Structure:
|
|
Vascular endothelial growth factor receptor 1. Chain: e, i, x. Fragment: domain-2, residues 132-226. Synonym: vegfr-1, fms-like tyrosine kinase 1, flt-1, tyrosine-protein kinase frt, tyrosine-protein kinase receptor flt, flt, vascular permeability factor receptor. Engineered: yes
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta-gami plyss.
|
|
Resolution:
|
|
|
2.00Å
|
R-factor:
|
0.181
|
R-free:
|
0.222
|
|
|
Authors:
|
|
J.-F.Gaucher,M.-B.Lascombe,M.Reille-Seroussi,N.Gagey-Eilstein, S.Broussy,P.Coric,B.Seijo,B.Gautier,W.-Q.Liu,F.Huguenot, N.Inguimbert,S.Bouaziz,M.Vidal,I.Broutin
|
|
Key ref:
|
|
J.F.Gaucher
et al.
(2016).
Biophysical Studies of the Induced Dimerization of Human VEGF Receptor 1 Binding Domain by Divalent Metals Competing with VEGF-A.
Plos One,
11,
e0167755.
PubMed id:
DOI:
|
|
|
Date:
|
|
|
05-Aug-15
|
Release date:
|
28-Sep-16
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
P17948
(VGFR1_HUMAN) -
Vascular endothelial growth factor receptor 1 from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
1338 a.a.
95 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
E.C.2.7.10.1
- receptor protein-tyrosine kinase.
|
|
|
|
|
|
|
Reaction:
|
|
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
|
|
|
|
|
|
L-tyrosyl-[protein]
|
+
|
ATP
|
=
|
O-phospho-L-tyrosyl-[protein]
|
+
|
ADP
|
+
|
H(+)
|
|
|
|
|
|
|
|
|
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
|
| |
|
DOI no:
|
Plos One
11:e0167755
(2016)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Biophysical Studies of the Induced Dimerization of Human VEGF Receptor 1 Binding Domain by Divalent Metals Competing with VEGF-A.
|
|
J.F.Gaucher,
M.Reille-Seroussi,
N.Gagey-Eilstein,
S.Broussy,
P.Coric,
B.Seijo,
M.B.Lascombe,
B.Gautier,
W.Q.Liu,
F.Huguenot,
N.Inguimbert,
S.Bouaziz,
M.Vidal,
I.Broutin.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Links
