UniProt functional annotation for E3TMG9



	UniProt functional annotation for E3TMG9

UniProt code: E3TMG9.

Organism: Saffold virus (SafV) (Human TMEV-like virus-Saffold).

Taxonomy: Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Picornavirales; Picornaviridae; Cardiovirus.

Function: Affects membrane integrity and causes an increase in membrane permeability. {ECO:0000256|ARBA:ARBA00004017}.

Function: Forms a primer, VPg-pU, which is utilized by the polymerase for the initiation of RNA chains. {ECO:0000256|ARBA:ARBA00002520}.

Function: Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. Together they form an icosahedral capsid composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms.VP4 lies on the inner surface of the protein shell formed by VP1, VP2 and VP3. All the three latter proteins contain a beta-sheet structure called beta-barrel jelly roll. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes. {ECO:0000256|ARBA:ARBA00002469}.

Function: Serves as membrane anchor via its hydrophobic domain. {ECO:0000256|ARBA:ARBA00003704}.

Function: VP0 precursor is a component of immature procapsids. {ECO:0000256|ARBA:ARBA00002982}.

Catalytic activity: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence={ECO:0000256|ARBA:ARBA00001556};

Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004180}. Host cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Host cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004295}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004295}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004295}. Host nucleus, host nucleolus {ECO:0000256|ARBA:ARBA00004307}. Membrane {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}. Virion {ECO:0000256|ARBA:ARBA00004328}.

Annotations taken from UniProtKB at the EBI.


Organism:		Saffold virus (SafV) (Human TMEV-like virus-Saffold).
Taxonomy:		Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Picornavirales; Picornaviridae; Cardiovirus.



Function:		Affects membrane integrity and causes an increase in membrane permeability. {ECO:0000256\|ARBA:ARBA00004017}.



Function:		Forms a primer, VPg-pU, which is utilized by the polymerase for the initiation of RNA chains. {ECO:0000256\|ARBA:ARBA00002520}.



Function:		Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. Together they form an icosahedral capsid composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms.VP4 lies on the inner surface of the protein shell formed by VP1, VP2 and VP3. All the three latter proteins contain a beta-sheet structure called beta-barrel jelly roll. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes. {ECO:0000256\|ARBA:ARBA00002469}.



Function:		Serves as membrane anchor via its hydrophobic domain. {ECO:0000256\|ARBA:ARBA00003704}.



Function:		VP0 precursor is a component of immature procapsids. {ECO:0000256\|ARBA:ARBA00002982}.


Catalytic activity:		Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence={ECO:0000256\|ARBA:ARBA00001556};
Subcellular location:		Cytoplasm {ECO:0000256\|ARBA:ARBA00004496}. Cytoplasmic vesicle membrane {ECO:0000256\|ARBA:ARBA00004180}; Peripheral membrane protein {ECO:0000256\|ARBA:ARBA00004180}; Cytoplasmic side {ECO:0000256\|ARBA:ARBA00004180}. Host cytoplasm {ECO:0000256\|ARBA:ARBA00004192}. Host cytoplasmic vesicle membrane {ECO:0000256\|ARBA:ARBA00004295}; Peripheral membrane protein {ECO:0000256\|ARBA:ARBA00004295}; Cytoplasmic side {ECO:0000256\|ARBA:ARBA00004295}. Host nucleus, host nucleolus {ECO:0000256\|ARBA:ARBA00004307}. Membrane {ECO:0000256\|ARBA:ARBA00004287}; Peripheral membrane protein {ECO:0000256\|ARBA:ARBA00004287}; Cytoplasmic side {ECO:0000256\|ARBA:ARBA00004287}. Virion {ECO:0000256\|ARBA:ARBA00004328}.