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UniProt functional annotation for P43588 | ||
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| UniProt code: P43588. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. RPN11 is the only catalytically active member of the lid and serves as the essential deubiquitinase of the proteasome. {ECO:0000269|PubMed:12183636, ECO:0000269|PubMed:21075847, ECO:0000269|PubMed:24463465}. |
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| Catalytic activity: | |
Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; |
| Subunit: | |
Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. Interacts directly with RPN8 and STS1. {ECO:0000269|PubMed:21075847, ECO:0000269|PubMed:23589842, ECO:0000269|PubMed:23911091, ECO:0000269|PubMed:24463465}. |
| Domain: | |
The JAMM motif is required for the deubiquitination and degradation of ubiquitinated substrates. {ECO:0000269|PubMed:12183636}. |
| Ptm: | |
N-acetylated by NAT3. {ECO:0000269|PubMed:12504901}. |
| Miscellaneous: | |
Present with 16400 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the peptidase M67A family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.