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UniProt functional annotation for O94742 | ||
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| UniProt code: O94742. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Versatile protein that might stabilize multiple protein complexes involved in diverse pathways. Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. Associates also with the TREX-2 complex that is required for transcription-coupled mRNA export, and the COP9 signalosome, which is involved in deneddylation. {ECO:0000269|PubMed:15117943, ECO:0000269|PubMed:19289793}. |
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| Subunit: | |
Part of the 26S proteasome. Associates with the nuclear pore complex (NPC)-associated TREX-2 complex and the COP9 signalosome. Interacts with CSN12 and THP3. {ECO:0000269|PubMed:19061648, ECO:0000269|PubMed:19289793}. |
| Disruption phenotype: | |
Impairs mRNA export and transcription elongation, and induces strong transcription-associated hyperrecombination phenotypes. {ECO:0000269|PubMed:19289793}. |
| Miscellaneous: | |
Present with 5590 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the DSS1/SEM1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.