UniProt functional annotation for Q9LVH4



	UniProt functional annotation for Q9LVH4

UniProt code: Q9LVH4.

Organism: Arabidopsis thaliana (Mouse-ear cress).

Taxonomy: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.

Function: Mediates the transient calcium-dependent interaction of PYR/PYL/RCAR abscisic acid (ABA) receptors with the plasma membrane and thus regulates ABA sensitivity (PubMed:26719420, PubMed:25465408). Stimulates the GTPase/ATPase activities of YchF1, and regulates its subcellular localization. Promotes tolerance towards salinity stress by limiting the accumulation of reactive oxygen species (ROS) (PubMed:23550829). Promotes resistance to bacterial pathogens (e.g. Xanthomonas oryzae pv. oryzae and P. syringae pv. tomato DC3000) (By similarity). Binds liposomes in the absence of exogenous Ca(2+), but this activity is enhanced in the presence of Ca(2+) and generates membrane curvature (PubMed:26719420). {ECO:0000250|UniProtKB:Q6YWF1, ECO:0000269|PubMed:23550829, ECO:0000269|PubMed:25465408, ECO:0000269|PubMed:26719420}.

Cofactor: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00041};

Subunit: Dimers and oligomers (PubMed:26719420). Binds to PYR/PYL/RCAR abscisic acid intracellular receptors in an ABA-independent manner, both at the plasma membrane and in the nucleus (PubMed:25465408, PubMed:26719420). Interacts directly with PYR1, PYL1, PYL4, PYL6 and PYL8 (PubMed:25465408, PubMed:26719420). Binds phospholipids in a Ca(2+)-dependent manner (PubMed:25465408). Interacts with YchF1 (PubMed:23550829). {ECO:0000269|PubMed:23550829, ECO:0000269|PubMed:25465408, ECO:0000269|PubMed:26719420}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:25465408, ECO:0000269|PubMed:26719420}. Nucleus {ECO:0000269|PubMed:25465408}. Cytoplasm, cytosol {ECO:0000269|PubMed:23550829, ECO:0000269|PubMed:26719420}. Note=Localized mainly in the cytosol under NaCl treatment, but translocates to the plasma membrane upon wounding. {ECO:0000269|PubMed:23550829}.

Disruption phenotype: When associated with disruption in CAR1, CAR5 and CAR9 genes, reduced sensitivity to abscisic acid (ABA) during seedling establishment and root growth regulation. {ECO:0000269|PubMed:25465408}.

Similarity: Belongs to the plant CAR protein family. {ECO:0000305|PubMed:25465408}.

Annotations taken from UniProtKB at the EBI.


Organism:		Arabidopsis thaliana (Mouse-ear cress).
Taxonomy:		Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.



Function:		Mediates the transient calcium-dependent interaction of PYR/PYL/RCAR abscisic acid (ABA) receptors with the plasma membrane and thus regulates ABA sensitivity (PubMed:26719420, PubMed:25465408). Stimulates the GTPase/ATPase activities of YchF1, and regulates its subcellular localization. Promotes tolerance towards salinity stress by limiting the accumulation of reactive oxygen species (ROS) (PubMed:23550829). Promotes resistance to bacterial pathogens (e.g. Xanthomonas oryzae pv. oryzae and P. syringae pv. tomato DC3000) (By similarity). Binds liposomes in the absence of exogenous Ca(2+), but this activity is enhanced in the presence of Ca(2+) and generates membrane curvature (PubMed:26719420). {ECO:0000250\|UniProtKB:Q6YWF1, ECO:0000269\|PubMed:23550829, ECO:0000269\|PubMed:25465408, ECO:0000269\|PubMed:26719420}.


Cofactor:		Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255\|PROSITE-ProRule:PRU00041};
Subunit:		Dimers and oligomers (PubMed:26719420). Binds to PYR/PYL/RCAR abscisic acid intracellular receptors in an ABA-independent manner, both at the plasma membrane and in the nucleus (PubMed:25465408, PubMed:26719420). Interacts directly with PYR1, PYL1, PYL4, PYL6 and PYL8 (PubMed:25465408, PubMed:26719420). Binds phospholipids in a Ca(2+)-dependent manner (PubMed:25465408). Interacts with YchF1 (PubMed:23550829). {ECO:0000269\|PubMed:23550829, ECO:0000269\|PubMed:25465408, ECO:0000269\|PubMed:26719420}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:25465408, ECO:0000269\|PubMed:26719420}. Nucleus {ECO:0000269\|PubMed:25465408}. Cytoplasm, cytosol {ECO:0000269\|PubMed:23550829, ECO:0000269\|PubMed:26719420}. Note=Localized mainly in the cytosol under NaCl treatment, but translocates to the plasma membrane upon wounding. {ECO:0000269\|PubMed:23550829}.
Disruption phenotype:		When associated with disruption in CAR1, CAR5 and CAR9 genes, reduced sensitivity to abscisic acid (ABA) during seedling establishment and root growth regulation. {ECO:0000269\|PubMed:25465408}.
Similarity:		Belongs to the plant CAR protein family. {ECO:0000305\|PubMed:25465408}.