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UniProt functional annotation for P62753 | ||
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| UniProt code: P62753. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Component of the 40S small ribosomal subunit (PubMed:8706699). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). {ECO:0000269|PubMed:17220279, ECO:0000269|PubMed:8706699}. |
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| Ptm: | |
Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the pre-initiation complex. {ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18974095, ECO:0000269|PubMed:21418524}. |
| Ptm: | |
Specifically hydroxylated (with R stereochemistry) at C-3 of Arg- 137 by KDM8. {ECO:0000269|PubMed:29563586}. |
| Similarity: | |
Belongs to the eukaryotic ribosomal protein eS6 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.