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UniProt functional annotation for P61247 | ||
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| UniProt code: P61247. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
May play a role during erythropoiesis through regulation of transcription factor DDIT3. {ECO:0000255|HAMAP-Rule:MF_03122}. |
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| Subunit: | |
Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3. {ECO:0000255|HAMAP-Rule:MF_03122, ECO:0000269|PubMed:11823430, ECO:0000269|PubMed:17289661}. |
| Subcellular location: | |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03122, ECO:0000269|PubMed:17289661}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03122}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
| Ptm: | |
ADP-ribosylated at Tyr-155 by PARP1 in presence of HPF1. {ECO:0000269|PubMed:29954836}. |
| Similarity: | |
Belongs to the eukaryotic ribosomal protein eS1 family. {ECO:0000255|HAMAP-Rule:MF_03122}. |
Annotations taken from UniProtKB at the EBI.