UniProt functional annotation for P08865



	UniProt functional annotation for P08865

UniProt code: P08865.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. {ECO:0000255|HAMAP- Rule:MF_03016, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:6300843}.

Function: (Microbial infection) Acts as a receptor for the Adeno- associated viruses 2,3,8 and 9. {ECO:0000269|PubMed:16973587}.

Function: (Microbial infection) Acts as a receptor for the Dengue virus. {ECO:0000269|PubMed:15507651}.

Function: (Microbial infection) Acts as a receptor for the Sindbis virus. {ECO:0000269|PubMed:1385835}.

Function: (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus. {ECO:0000269|PubMed:1385835}.

Function: (Microbial infection) Acts as a receptor for the pathogenic prion protein. {ECO:0000269|PubMed:11689427, ECO:0000269|PubMed:9396609}.

Function: (Microbial infection) Acts as a receptor for bacteria. {ECO:0000269|PubMed:15516338}.

Subunit: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK (By similarity). The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B. {ECO:0000255|HAMAP-Rule:MF_03016, ECO:0000269|PubMed:10079194, ECO:0000269|PubMed:10772861, ECO:0000269|PubMed:11689427, ECO:0000269|PubMed:15507651, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:1834645, ECO:0000269|PubMed:6300843, ECO:0000269|PubMed:8433567, ECO:0000269|PubMed:9396609, ECO:0000269|PubMed:9718729}.

Subunit: (Microbial infection) 67LR interacts with capsid protein of Adeno-associated virus 2,3,8 and 9. {ECO:0000269|PubMed:16973587}.

Subunit: (Microbial infection) 67LR interacts with envelope protein of dengue virus. {ECO:0000269|PubMed:15507651}.

Subunit: (Microbial infection) 6s7LR interacts with E2 glycoprotein of Sindbis and Venezuelan equine encephalitis virus (PubMed:8764073, PubMed:1385835). {ECO:0000269|PubMed:1385835, ECO:0000269|PubMed:8764073}.

Subcellular location: Cell membrane. Cytoplasm. Nucleus {ECO:0000255|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Colocalizes with PPP1R16B in the cell membrane. {ECO:0000255|HAMAP- Rule:MF_03016}.

Ptm: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association (PubMed:9581863). {ECO:0000255|HAMAP- Rule:MF_03016, ECO:0000269|PubMed:9581863}.

Ptm: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions. {ECO:0000255|HAMAP-Rule:MF_03016}.

Disease: Asplenia, isolated congenital (ICAS) [MIM:271400]: A rare primary immunodeficiency and life-threatening condition, often presenting with pneumococcal sepsis. Most affected individuals die of severe bacterial infections in early childhood. Isolated asplenia is distinct from asplenia associated with other complex visceral defects, notably heterotaxy syndromes such as Ivemark syndrome. {ECO:0000269|PubMed:23579497}. Note=The disease is caused by variants affecting the gene represented in this entry.

Miscellaneous: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

Miscellaneous: It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.

Similarity: Belongs to the universal ribosomal protein uS2 family. {ECO:0000255|HAMAP-Rule:MF_03016}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. {ECO:0000255\|HAMAP- Rule:MF_03016, ECO:0000269\|PubMed:16263087, ECO:0000269\|PubMed:6300843}.



Function:		(Microbial infection) Acts as a receptor for the Adeno- associated viruses 2,3,8 and 9. {ECO:0000269\|PubMed:16973587}.



Function:		(Microbial infection) Acts as a receptor for the Dengue virus. {ECO:0000269\|PubMed:15507651}.



Function:		(Microbial infection) Acts as a receptor for the Sindbis virus. {ECO:0000269\|PubMed:1385835}.



Function:		(Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus. {ECO:0000269\|PubMed:1385835}.



Function:		(Microbial infection) Acts as a receptor for the pathogenic prion protein. {ECO:0000269\|PubMed:11689427, ECO:0000269\|PubMed:9396609}.



Function:		(Microbial infection) Acts as a receptor for bacteria. {ECO:0000269\|PubMed:15516338}.


Subunit:		Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK (By similarity). The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B. {ECO:0000255\|HAMAP-Rule:MF_03016, ECO:0000269\|PubMed:10079194, ECO:0000269\|PubMed:10772861, ECO:0000269\|PubMed:11689427, ECO:0000269\|PubMed:15507651, ECO:0000269\|PubMed:16263087, ECO:0000269\|PubMed:1834645, ECO:0000269\|PubMed:6300843, ECO:0000269\|PubMed:8433567, ECO:0000269\|PubMed:9396609, ECO:0000269\|PubMed:9718729}.
Subunit:		(Microbial infection) 67LR interacts with capsid protein of Adeno-associated virus 2,3,8 and 9. {ECO:0000269\|PubMed:16973587}.
Subunit:		(Microbial infection) 67LR interacts with envelope protein of dengue virus. {ECO:0000269\|PubMed:15507651}.
Subunit:		(Microbial infection) 6s7LR interacts with E2 glycoprotein of Sindbis and Venezuelan equine encephalitis virus (PubMed:8764073, PubMed:1385835). {ECO:0000269\|PubMed:1385835, ECO:0000269\|PubMed:8764073}.
Subcellular location:		Cell membrane. Cytoplasm. Nucleus {ECO:0000255\|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Colocalizes with PPP1R16B in the cell membrane. {ECO:0000255\|HAMAP- Rule:MF_03016}.
Ptm:		Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association (PubMed:9581863). {ECO:0000255\|HAMAP- Rule:MF_03016, ECO:0000269\|PubMed:9581863}.
Ptm:		Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions. {ECO:0000255\|HAMAP-Rule:MF_03016}.
Disease:		Asplenia, isolated congenital (ICAS) [MIM:271400]: A rare primary immunodeficiency and life-threatening condition, often presenting with pneumococcal sepsis. Most affected individuals die of severe bacterial infections in early childhood. Isolated asplenia is distinct from asplenia associated with other complex visceral defects, notably heterotaxy syndromes such as Ivemark syndrome. {ECO:0000269\|PubMed:23579497}. Note=The disease is caused by variants affecting the gene represented in this entry.
Miscellaneous:		This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.
Miscellaneous:		It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.
Similarity:		Belongs to the universal ribosomal protein uS2 family. {ECO:0000255\|HAMAP-Rule:MF_03016}.