PDBsum entry 5z1c

Hydrolase

PDB id: 5z1c

Contents

Protein chain

245 a.a.

Ligands

ZXI

Waters ×161

PDB id:

5z1c

Name:

Hydrolase

Title:

The crystal structure of upa in complex with 4-iodobenzylamine at ph7.4

Structure:

Urokinase-type plasminogen activator. Chain: u. Synonym: upa. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922

Resolution:

1.45Å R-factor: 0.119 R-free: 0.143

Authors:

L.G.Jiang,X.Zhang,Z.P.Luo,M.D.Huang

Key ref:

L.G.Jiang et al. (2018). Halogen bonding for the design of inhibitors by targe the s1 pocket of serine proteases. Rsc adv, 49, 28189.

Date:

25-Dec-17 Release date: 26-Dec-18

Protein chain

P00749  (UROK_HUMAN) -  Urokinase-type plasminogen activator from Homo sapiens

Seq: 431 a.a.

Struc: 245 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.4.21.73 - u-plasminogen activator.
• Reaction: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.