PDBsum entry 5yc7

Hydrolase/hydrolase inhibitor

PDB id: 5yc7

Contents

Protein chain

246 a.a.

Ligands

PZH

SO4

Waters ×39

PDB id:

5yc7

Name:

Hydrolase/hydrolase inhibitor

Title:

The crystal structure of upa in complex with 4-bromobenzylamirne at ph7.4

Structure:

Urokinase-type plasminogen activator. Chain: u. Fragment: urokinase-type plasminogen activator chain b, unp residues 179-324. Synonym: upa. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922

Resolution:

2.00Å R-factor: 0.214 R-free: 0.262

Authors:

L.G.Jiang,X.Zhang,M.D.Huang

Key ref:

L.G.Jiang et al. (2018). Halogen bonding for the design of inhibitors by targe the s1 pocket of serine proteases. Rsc adv, 8, 28189.

Date:

06-Sep-17 Release date: 03-Oct-18

Supersedes:

4jnl

Protein chain

P00749  (UROK_HUMAN) -  Urokinase-type plasminogen activator from Homo sapiens

Seq: 431 a.a.

Struc: 246 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.4.21.73 - u-plasminogen activator.
• Reaction: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.