PDBsum entry 5vpl

Hydrolase/immune system

PDB id: 5vpl

Contents

Protein chains

223 a.a.

211 a.a.

216 a.a.

Ligands

NAG

EDO ×4

Metals

_CA

Waters ×650

PDB id:

5vpl

Name:

Hydrolase/immune system

Title:

Crystal structure of der f 1 complexed with fab 4c1

Structure:

Der f 1 variant. Chain: a. Fragment: unp residues 99-321. 4c1 - light chain. Chain: c. Engineered: yes. 4c1 - heavy chain. Chain: d. Engineered: yes

Source:

Dermatophagoides farinae. American house dust mite. Organism_taxid: 6954. Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: mus musculus. Expression_system_taxid: 10090. Expression_system_cell_line: hybridoma.

Resolution:

1.90Å R-factor: 0.154 R-free: 0.194

Authors:

M.Chruszcz,L.D.Vailes,M.D.Chapman,A.Pomes,W.Minor

Key ref:

M.Chruszcz et al. (2012). Molecular determinants for antibody binding on group 1 house dust mite allergens. J Biol Chem, 287, 7388-7398. PubMed id: 22210776

Date:

05-May-17 Release date: 24-May-17

Supersedes:

3rvv

Protein chain

I2CMD3  (I2CMD3_DERFA) -  Der f 1 variant (Fragment) from Dermatophagoides farinae

Seq: 305 a.a.

Struc: 223 a.a.

Protein chain

Q7TS98  (Q7TS98_MOUSE) -  Anti-colorectal carcinoma light chain from Mus musculus

Seq: 236 a.a.

Struc: 211 a.a.*

Protein chain

No UniProt id for this chain

Struc: 216 a.a.

* PDB and UniProt seqs differ at 11 residue positions (black crosses)

J Biol Chem 287:7388-7398 (2012)

PubMed id: 22210776

Molecular determinants for antibody binding on group 1 house dust mite allergens.

M.Chruszcz, A.Pomés, J.Glesner, L.D.Vailes, T.Osinski, P.J.Porebski, K.A.Majorek, P.W.Heymann, T.A.Platts-Mills, W.Minor, M.D.Chapman.

ABSTRACT

No abstract given.