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PDBsum entry 5syn
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Hydrolase/hydrolase inhibitor
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PDB id
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5syn
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PDB id:
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| Name: |
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Hydrolase/hydrolase inhibitor
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Title:
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Cocrystal structure of the human acyl protein thioesterase 2 with an isoform-selective inhibitor, ml349
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Structure:
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Acyl-protein thioesterase 2. Chain: a, b, c, d. Synonym: apt-2,lysophospholipase ii,lysopla ii. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: lypla2, apt2. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.64Å
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R-factor:
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0.220
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R-free:
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0.250
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Authors:
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J.A.Stuckey,K.J.Labby,J.L.Meagher,S.J.Won,B.R.Martin
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Key ref:
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S.J.Won
et al.
(2016).
Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2).
Acs Chem Biol,
11,
3374-3382.
PubMed id:
DOI:
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Date:
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11-Aug-16
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Release date:
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26-Oct-16
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PROCHECK
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Headers
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References
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O95372
(LYPA2_HUMAN) -
Acyl-protein thioesterase 2 from Homo sapiens
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Seq:
Struc:
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231 a.a.
223 a.a.
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Key: |
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Secondary structure |
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CATH domain |
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Enzyme class 2:
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E.C.3.1.2.-
- ?????
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Enzyme class 3:
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E.C.3.1.2.22
- palmitoyl-protein hydrolase.
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Reaction:
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S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H+
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S-hexadecanoyl-L-cysteinyl-[protein]
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+
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H2O
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=
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L-cysteinyl-[protein]
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+
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hexadecanoate
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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DOI no:
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Acs Chem Biol
11:3374-3382
(2016)
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PubMed id:
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Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2).
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S.J.Won,
D.Davda,
K.J.Labby,
S.Y.Hwang,
R.Pricer,
J.D.Majmudar,
K.A.Armacost,
L.A.Rodriguez,
C.L.Rodriguez,
F.S.Chong,
K.A.Torossian,
J.Palakurthi,
E.S.Hur,
J.L.Meagher,
C.L.Brooks,
J.A.Stuckey,
B.R.Martin.
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ABSTRACT
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Links
