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UniProt functional annotation for O43776 | ||
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| UniProt code: O43776. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Catalyzes the attachment of asparagine to tRNA(Asn) in a two- step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:9421509). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells (PubMed:30171954, PubMed:12235211). {ECO:0000269|PubMed:12235211, ECO:0000269|PubMed:30171954, ECO:0000269|PubMed:9421509}. |
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| Catalytic activity: | |
Reaction=ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L- asparaginyl-tRNA(Asn); Xref=Rhea:RHEA:11180, Rhea:RHEA-COMP:9659, Rhea:RHEA-COMP:9674, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58048, ChEBI:CHEBI:78442, ChEBI:CHEBI:78515, ChEBI:CHEBI:456215; EC=6.1.1.22; Evidence={ECO:0000269|PubMed:9421509}; |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:30171954}. |
| Subcellular location: | |
Cytoplasm {ECO:0000305|PubMed:9421509}. |
| Domain: | |
The N-terminal domain (1-77) recruits and activates specific immune cells by interacting with CCR3-expressing cells. {ECO:0000269|PubMed:30171954}. |
| Miscellaneous: | |
Autoantibodies to NARS1, are often detected in sera from patients with interstitial lung disease (ILD). {ECO:0000269|PubMed:9973509}. |
| Similarity: | |
Belongs to the class-II aminoacyl-tRNA synthetase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.