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PDBsum entry 4zxb
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Hormone receptor/immune system
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PDB id
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4zxb
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Contents |
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214 a.a.
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218 a.a.
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187 a.a.
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182 a.a.
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800 a.a.
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References listed in PDB file
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Key reference
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Title
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Higher-Resolution structure of the human insulin receptor ectodomain: multi-Modal inclusion of the insert domain.
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Authors
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T.I.Croll,
B.J.Smith,
M.B.Margetts,
J.Whittaker,
M.A.Weiss,
C.W.Ward,
M.C.Lawrence.
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Ref.
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Structure, 2016,
24,
469-476.
[DOI no: ]
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PubMed id
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Abstract
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Insulin receptor (IR) signaling is critical to controlling nutrient uptake and
metabolism. However, only a low-resolution (3.8 Å) structure currently exists
for the IR ectodomain, with some segments ill-defined or unmodeled due to
disorder. Here, we revise this structure using new diffraction data to 3.3 Å
resolution that allow improved modeling of the N-linked glycans, the first and
third fibronectin type III domains, and the insert domain. A novel haptic
interactive molecular dynamics strategy was used to aid fitting to
low-resolution electron density maps. The resulting model provides a foundation
for investigation of structural transitions in IR upon ligand binding.
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