UniProt functional annotation for Q8R3Z5



	UniProt functional annotation for Q8R3Z5

UniProt code: Q8R3Z5.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore- forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (By similarity). {ECO:0000250|UniProtKB:P19517, ECO:0000250|UniProtKB:Q02641}.

Subunit: Regulatory subunit of L-type calcium channels that consist of a pore-forming alpha subunit and auxiliary beta, gamma and delta subunits. Interacts with CACNA1A, CACNA1B, CACNA1C and CACNA1S. Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1 (By similarity). Interacts with CACNA1S (PubMed:28351836). Identified in a complex with CACNA1C. Identified in a complex with the L-type calcium channel subunits CACNA1C, CACNA2D1, CACNB1 and one of the gamma subunits (CACNG4, CACNG6, CACNG7, or CACNG8) (By similarity). Part of a L-type calcium channel complex that contains CACNA1D, CACNA2D1 and CACNB1. Part of a L-type calcium channel complex that contains CACNA1B, CACNA2D1 and CACNB1 (By similarity). Interacts with JSRP1 (PubMed:16638807). Interacts with RYR1 (PubMed:21320436). Interacts with CBARP (PubMed:24751537). {ECO:0000250|UniProtKB:P19517, ECO:0000250|UniProtKB:Q02641, ECO:0000269|PubMed:16638807, ECO:0000269|PubMed:21320436, ECO:0000269|PubMed:24751537, ECO:0000269|PubMed:28351836}.

Subcellular location: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P19517}; Peripheral membrane protein {ECO:0000250|UniProtKB:P19517}; Cytoplasmic side {ECO:0000250|UniProtKB:P19517}. Cell membrane {ECO:0000305|PubMed:21831364}; Peripheral membrane protein {ECO:0000250|UniProtKB:P19517}.

Tissue specificity: Detected in the inner nuclear layer in the retina (at protein level) (PubMed:21831364). Detected in skeletal muscle, brain, heart and spleen (PubMed:1385409). {ECO:0000269|PubMed:1385409, ECO:0000269|PubMed:21831364}.

Similarity: Belongs to the calcium channel beta subunit family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore- forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (By similarity). {ECO:0000250\|UniProtKB:P19517, ECO:0000250\|UniProtKB:Q02641}.


Subunit:		Regulatory subunit of L-type calcium channels that consist of a pore-forming alpha subunit and auxiliary beta, gamma and delta subunits. Interacts with CACNA1A, CACNA1B, CACNA1C and CACNA1S. Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1 (By similarity). Interacts with CACNA1S (PubMed:28351836). Identified in a complex with CACNA1C. Identified in a complex with the L-type calcium channel subunits CACNA1C, CACNA2D1, CACNB1 and one of the gamma subunits (CACNG4, CACNG6, CACNG7, or CACNG8) (By similarity). Part of a L-type calcium channel complex that contains CACNA1D, CACNA2D1 and CACNB1. Part of a L-type calcium channel complex that contains CACNA1B, CACNA2D1 and CACNB1 (By similarity). Interacts with JSRP1 (PubMed:16638807). Interacts with RYR1 (PubMed:21320436). Interacts with CBARP (PubMed:24751537). {ECO:0000250\|UniProtKB:P19517, ECO:0000250\|UniProtKB:Q02641, ECO:0000269\|PubMed:16638807, ECO:0000269\|PubMed:21320436, ECO:0000269\|PubMed:24751537, ECO:0000269\|PubMed:28351836}.
Subcellular location:		Cell membrane, sarcolemma {ECO:0000250\|UniProtKB:P19517}; Peripheral membrane protein {ECO:0000250\|UniProtKB:P19517}; Cytoplasmic side {ECO:0000250\|UniProtKB:P19517}. Cell membrane {ECO:0000305\|PubMed:21831364}; Peripheral membrane protein {ECO:0000250\|UniProtKB:P19517}.
Tissue specificity:		Detected in the inner nuclear layer in the retina (at protein level) (PubMed:21831364). Detected in skeletal muscle, brain, heart and spleen (PubMed:1385409). {ECO:0000269\|PubMed:1385409, ECO:0000269\|PubMed:21831364}.
Similarity:		Belongs to the calcium channel beta subunit family. {ECO:0000305}.