PDBsum entry 4zw1

Transcription/inhibitor

PDB id: 4zw1

Contents

Protein chain

124 a.a.

Ligands

4V1

EDO ×2

Waters ×101

PDB id:

4zw1

Name:

Transcription/inhibitor

Title:

Crystal structure of hbrd4 in complex with bl-bi06 reveals a novel synthesized inhibitor that induces beclin1-independent/atg5-dependent autophagic cell death in breast cancer

Structure:

Bromodomain-containing protein 4. Chain: a. Fragment: unp residues 44-168. Synonym: protein hunk1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: brd4, hunk1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.75Å R-factor: 0.188 R-free: 0.249

Authors:

B.Liu,S.Zhang,M.Guo,M.Tian

Key ref:

B.Liu et al. Crystal structure of hbrd4 in complex with bl-Bi06 re novel synthesized inhibitor that induces beclin1-Independent/atg5-Dependent autophagic cell de breast cancer. To be published, .

Date:

19-May-15 Release date: 22-Jun-16

Protein chain

O60885  (BRD4_HUMAN) -  Bromodomain-containing protein 4 from Homo sapiens

Seq: 1362 a.a.

Struc: 124 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)