PDBsum entry 4zrv

Sugar binding protein

PDB id: 4zrv

Contents

Protein chains

132 a.a.

Ligands

GLC-U8V ×3

ACT ×3

Metals

_CA ×9

Waters ×372

PDB id:

4zrv

Name:

Sugar binding protein

Title:

Structure of cow mincle crd complexed with trehalose mono butyrate

Structure:

Mincle crd. Chain: a, b, c. Fragment: unp residues 79-208. Engineered: yes

Source:

Bos taurus. Bovine. Organism_taxid: 9913. Gene: clec4e. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.10Å R-factor: 0.166 R-free: 0.208

Authors:

H.Feinberg,N.D.S.Rambaruth,M.E.Taylor,K.Drickamer,W.I.Weis

Key ref:

H.Feinberg et al. (2016). Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle. J Biol Chem, 291, 21222-21233. PubMed id: 27542410 DOI: 10.1074/jbc.M116.749515

Date:

12-May-15 Release date: 25-May-16

Protein chains

E1BHM0  (E1BHM0_BOVIN) -  C-type lectin domain family 4 member E from Bos taurus

Seq: 211 a.a.

Struc: 132 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

DOI no: 10.1074/jbc.M116.749515

J Biol Chem 291:21222-21233 (2016)

PubMed id: 27542410

Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle.

H.Feinberg, N.D.Rambaruth, S.A.Jégouzo, K.M.Jacobsen, R.Djurhuus, T.B.Poulsen, W.I.Weis, M.E.Taylor, K.Drickamer.

ABSTRACT

No abstract given.