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PDBsum entry 4zqk
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Immune system
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PDB id
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4zqk
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References listed in PDB file
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Key reference
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Title
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Structure of the complex of human programmed death 1, Pd-1, And its ligand pd-L1.
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Authors
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K.M.Zak,
R.Kitel,
S.Przetocka,
P.Golik,
K.Guzik,
B.Musielak,
A.Dömling,
G.Dubin,
T.A.Holak.
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Ref.
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Structure, 2015,
23,
2341-2348.
[DOI no: ]
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PubMed id
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Abstract
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Targeting the PD-1/PD-L1 immunologic checkpoint with monoclonal antibodies has
recently provided breakthrough progress in the treatment of melanoma, non-small
cell lung cancer, and other types of cancer. Small-molecule drugs interfering
with this pathway are highly awaited, but their development is hindered by
insufficient structural information. This study reveals the molecular details of
the human PD-1/PD-L1 interaction based on an X-ray structure of the complex.
First, it is shown that the ligand binding to human PD-1 is associated with
significant plasticity within the receptor. Second, a detailed molecular map of
the interaction surface is provided, allowing definition of the regions within
both interacting partners that may likely be targeted by small molecules.
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