PDBsum entry 4zog

Transferase

PDB id: 4zog

Contents

Protein chains

269 a.a.

Ligands

VX6 ×2

MXE ×3

MES

Waters ×125

PDB id:

4zog

Name:

Transferase

Title:

Vx-680/mk-0457 binds to human abl1 also in inactive dfg conformations.

Structure:

Tyrosine-protein kinase abl1. Chain: a, b. Fragment: unp residues 229-511. Synonym: abelson murine leukemia viral oncogene homolog 1,abelson tyrosine-protein kinase 1,proto-oncogenE C-abl,p150. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star.

Resolution:

2.30Å R-factor: 0.187 R-free: 0.233

Authors:

P.Kyomuhendo,D.Narayanan,R.A.Engh

Key ref:

P.Kyomuhendo et al. Vx-680/mk-0457 binds also to human abl1 with inactive conformations.. To be published, .

Date:

06-May-15 Release date: 14-Sep-16

Protein chains

P00519  (ABL1_HUMAN) -  Tyrosine-protein kinase ABL1 from Homo sapiens

Seq: 1130 a.a.

Struc: 269 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site