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UniProt functional annotation for P15273 | ||
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| UniProt code: P15273. |
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| Organism: | |
Yersinia enterocolitica. |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Yersiniaceae; Yersinia. |
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| Function: | |
Essential virulence determinant. This protein is a protein tyrosine phosphatase. The essential function of YopH in Yersinia pathogenesis is host-protein dephosphorylation. It contributes to the ability of the bacteria to resist phagocytosis by peritoneal macrophages. {ECO:0000269|PubMed:2166336}. |
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| Catalytic activity: | |
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE- ProRule:PRU10044, ECO:0000269|PubMed:2166336}; |
| Subunit: | |
Monomer. |
| Subcellular location: | |
Secreted. Note=Secreted via type III secretion system. |
| Induction: | |
At 37 degrees Celsius in the absence of calcium. |
| Similarity: | |
Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.