PDBsum entry 4zh8

Hydrolase

PDB id: 4zh8

Contents

Protein chains

234 a.a.

52 a.a.

Ligands

4O4

Metals

_CA

Waters ×271

PDB id:

4zh8

Name:

Hydrolase

Title:

Factor xa complex with gtc000006

Structure:

Coagulation factor x. Chain: a. Fragment: residues 235 - 488. Synonym: stuart factor,stuart-prower factor. Coagulation factor x. Chain: b. Fragment: residues 43-179. Synonym: stuart factor,stuart-prower factor. Ec: 3.4.21.6

Source:

Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606

Resolution:

1.80Å R-factor: 0.209 R-free: 0.255

Authors:

M.A.Convery

Key ref:

M.A.Convery Factor xa complex with gtc000006. To be published, .

Date:

24-Apr-15 Release date: 13-Jan-16

Protein chain

P00742  (FA10_HUMAN) -  Coagulation factor X from Homo sapiens

Seq: 488 a.a.

Struc: 234 a.a.

Protein chain

P00742  (FA10_HUMAN) -  Coagulation factor X from Homo sapiens

Seq: 488 a.a.

Struc: 52 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.4.21.6 - coagulation factor Xa.
• Reaction: Preferential cleavage: Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.