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UniProt functional annotation for O15123 | ||
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| UniProt code: O15123. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. {ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:19116766, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:9204896}. |
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| Subunit: | |
Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. {ECO:0000269|PubMed:12427764, ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:16732286, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:9204896}. |
| Subcellular location: | |
Secreted. |
| Domain: | |
The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor. |
Annotations taken from UniProtKB at the EBI.