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UniProt functional annotation for P91645 | ||
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| UniProt code: P91645. |
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| Organism: | |
Drosophila melanogaster (Fruit fly). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. |
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| Function: | |
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (By similarity). Probably encodes a dihydropyridine- insensitive current. Vital for survival to adulthood. {ECO:0000250|UniProtKB:O00555, ECO:0000269|PubMed:28742085, ECO:0000269|PubMed:8987815, ECO:0000269|PubMed:9649530}. |
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| Subcellular location: | |
Membrane {ECO:0000305}; Multi-pass membrane protein. |
| Tissue specificity: | |
Expressed widely in the embryonic nervous system. {ECO:0000269|PubMed:8987815}. |
| Developmental stage: | |
Expression peaks in the first larval instar, midpupal, and late pupal stages. In late-stage embryos, it is expressed preferentially in the nervous system. {ECO:0000269|PubMed:8987815}. |
| Domain: | |
Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage- sensor and are characterized by a series of positively charged amino acids at every third position. |
| Rna editing: | |
Modified_positions=Undetermined; Note=Partially edited. 11 sites are edited by Adar. {ECO:0000269|PubMed:10966106}; |
| Miscellaneous: | |
[Isoform E]: Has exons IS4B and I/IIA. |
| Miscellaneous: | |
[Isoform A]: Has exons IS4B and I/IIA. {ECO:0000305}. |
| Miscellaneous: | |
[Isoform B]: Has exons IS4A and I/IIA. {ECO:0000305}. |
| Miscellaneous: | |
[Isoform C]: Has exons IS4B and I/IIB. {ECO:0000305}. |
| Miscellaneous: | |
[Isoform D]: Has exons IS4A and I/IIB. {ECO:0000305}. |
| Miscellaneous: | |
[Isoform F]: Has exons IS4A and I/IIB. {ECO:0000305}. |
| Similarity: | |
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.