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UniProt functional annotation for Q7Z6K5 | ||
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| UniProt code: Q7Z6K5. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence. {ECO:0000269|PubMed:24132237}. |
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| Subunit: | |
Associates with the Arp2/3 complex. Interacts with ARPC2; enhanced by activated RAC1. Interacts with ARPC5; the interaction is dependent on RAC1. {ECO:0000269|PubMed:24132237}. |
| Subcellular location: | |
Cell projection, lamellipodium {ECO:0000250}. Note=Colocalized with the WAVE complex at lamelliupodium tip. {ECO:0000250}. |
| Domain: | |
The acidic C-terminus is necessary and sufficient to inhibit ARP2/3 complex activity. {ECO:0000269|PubMed:24132237}. |
| Miscellaneous: | |
[Isoform C15orf38-AP3S2]: Based on a naturally occurring readthrough transcript which produces a C15orf38-AP3S2 fusion protein. {ECO:0000305}. |
| Similarity: | |
Belongs to the Arpin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.