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UniProt functional annotation for Q86VP1 | ||
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| UniProt code: Q86VP1. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205}. |
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| Subunit: | |
Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1. {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:14530271, ECO:0000269|PubMed:14697242}. |
| Tissue specificity: | |
Expressed in all tissues tested. |
| Domain: | |
The C-terminal UBZ-type zinc fingers function as ubiquitin- binding domains. {ECO:0000269|PubMed:24239949}. |
| Ptm: | |
Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation. {ECO:0000269|PubMed:21765415}. |
| Sequence caution: | |
Sequence=AAC13359.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.