PDBsum entry 4yzb

Transferase/transferase inhibitor

PDB id: 4yzb

Contents

Protein chains

466 a.a.

Ligands

BK8 ×2

Metals

_CA ×8

PDB id:

4yzb

Name:

Transferase/transferase inhibitor

Title:

Cdpk1 from eimeria tenella in complex with inhibitor uw1521

Structure:

Calmodulin-like domain protein kinase. Chain: a, b. Fragment: full length. Engineered: yes. Other_details: note that unp sequence q3hnm4 incorrectly shows an ala instead of the conserved residue asp 392 at ca binding site 2.

Source:

Eimeria tenella. Coccidian parasite. Organism_taxid: 5802. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.90Å R-factor: 0.244 R-free: 0.284

Authors:

E.A.Merritt

Key ref:

K.K.Ojo et al. Cdpk is a druggable target in the apicomplexan parasi eimeria. To be published, .

Date:

24-Mar-15 Release date: 06-Apr-16

Protein chains

Q3HNM4  (Q3HNM4_EIMTE) -  non-specific serine/threonine protein kinase from Eimeria tenella

Seq: 505 a.a.

Struc: 466 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site