UniProt functional annotation for O43660



	UniProt functional annotation for O43660

UniProt code: O43660.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257). {ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}.

Subunit: Identified in the spliceosome C complex (PubMed:12176931, PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8 (PubMed:11101529, PubMed:20176811). Interacts (via its WD40 repeat domain) directly with CDC5L (via its C-terminal); the interaction is required for mRNA splicing but not for spliceosome assembly (PubMed:11544257). Also interacts directly in the complex with BCAS2 and PRPF19 (PubMed:20176811). {ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:12176931, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}.

Subcellular location: Nucleus {ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. Nucleus speckle {ECO:0000269|PubMed:11544257}.

Miscellaneous: [Isoform 2]: May be due to a competing donor splice site. {ECO:0000305}.

Similarity: Belongs to the WD repeat PRL1/PRL2 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257). {ECO:0000269\|PubMed:11101529, ECO:0000269\|PubMed:11544257, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770}.


Subunit:		Identified in the spliceosome C complex (PubMed:12176931, PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8 (PubMed:11101529, PubMed:20176811). Interacts (via its WD40 repeat domain) directly with CDC5L (via its C-terminal); the interaction is required for mRNA splicing but not for spliceosome assembly (PubMed:11544257). Also interacts directly in the complex with BCAS2 and PRPF19 (PubMed:20176811). {ECO:0000269\|PubMed:11101529, ECO:0000269\|PubMed:11544257, ECO:0000269\|PubMed:12176931, ECO:0000269\|PubMed:20176811, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:11101529, ECO:0000269\|PubMed:20176811, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770}. Nucleus speckle {ECO:0000269\|PubMed:11544257}.
Miscellaneous:		[Isoform 2]: May be due to a competing donor splice site. {ECO:0000305}.
Similarity:		Belongs to the WD repeat PRL1/PRL2 family. {ECO:0000305}.